Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases.

Abstract

After transplantation of human tissue to nu/nu mice the human lymphocytes disappear. In this context, interestingly, the DR-expression is not detectable anymore after transplantation of the tissues from patients with autoimmune thyrotoxicosis and cancer. Neopterin release was only demonstrable when T-lymphocytes from patients with autoimmune thyrotoxicosis or PHA-stimulated lymphocytes were added, independently of the presence of DR-expression in the used culture tissues. These results seem to exclude a functional role of DR-expression as a trigger mechanism of autoimmunity. It is supposed that DR-priming on epithelial cells is mediated by kinine production of activated T-lymphocytes or macrophages.

• Authors: K H Usadel, J Teuber, R Paschke, M Junker, U Schwedes
• Journal: Acta endocrinologica. Supplementum (Acta Endocrinol Suppl (Copenh)) Vol. 281 Pg. 77-81 ( 1987) ISSN: 0300-9750 [Print] Denmark
• PMID: 3497513 (Publication Type: Journal Article)

Chemical References

• HLA-DR Antigens

Topics

• Animals
• HLA-DR Antigens (analysis, genetics)
• Humans
• Mice
• Mice, Nude
• T-Lymphocytes (immunology, transplantation)
• Thyroid Gland (immunology, transplantation)
• Thyroid Neoplasms (immunology)
• Thyroiditis, Autoimmune (etiology, immunology)
• Transplantation, Heterologous