Abstract |
The time course of immunosuppression induced by acute treatment with O,O,S-trimethyl phosphorothioate ( OOS-TMP), an impurity in technical formulations of malathion, was examined in female C57B1/6 mice. Both cell-mediated and humoral immune responses were examined and included allospecific cytotoxic T cells, proliferative response to mitogens, interleukin-2 production and antibody production to sheep red blood cells. OOS-TMP pretreatment led to a reversible suppression of the generation of cytotoxic T lymphocytes and antibody-secreting cells to sheep erythrocytes. However, the mitogenic response of splenocytes from animals treated with nontoxic doses of OOS-TMP (as measured by body weight loss, serum cholinesterase levels and splenic lymphocyte number) to concanavalin A was not significantly suppressed, but the response to the B cell mitogen lipopolysaccharide was slightly decreased on day 1 following treatment. In contrast, interleukin-2 production was elevated by 24 h following treatment, but had returned to control levels by day 7. These data suggest that OOS-TMP was able to block the generation of cytotoxic T lymphocytes and antibody responses at doses of OOS-TMP that did not affect body weight or splenic lymphocyte number and this suppression was reversible.
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Authors | K E Rodgers, T Imamura, B H Devens |
Journal | Immunopharmacology
(Immunopharmacology)
Vol. 12
Issue 3
Pg. 193-202
(Dec 1986)
ISSN: 0162-3109 [Print] Netherlands |
PMID | 3493228
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Interleukin-2
- Organothiophosphates
- Organothiophosphorus Compounds
- O,O,S-trimethyl phosphorothioate
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Topics |
- Animals
- Antibody Formation
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Immunity, Cellular
(drug effects)
- Interleukin-2
(biosynthesis)
- Lymphocyte Activation
(drug effects)
- Mice
- Mice, Inbred C57BL
- Organothiophosphates
(toxicity)
- Organothiophosphorus Compounds
(toxicity)
- T-Lymphocytes, Cytotoxic
(drug effects, immunology)
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