A new chemical compound, 11-oxo-11H-pyrido[2,1-b]
quinazoline-2-
carboxylic acid (
Sm 857), known to have
antiallergic activity was investigated with respect to its antiinflammatory effect.
Sm 857 did not inhibit ultraviolet-induced
erythema in guinea pigs, intradermal increased vascular permeability induced by
histamine in rats and
carrageenin-induced
edema of the rat hind paw. Further, the compound showed no influence on wound healing in rats and was observed to exert neither
analgesic nor inhibitory effect on platelet aggregation.
Sm 857 was thus found to have no effect at all on acute and chronic inflammatory reactions. It was denied, therefore, that any antiinflammatory effect might be involved in the
antiallergic effect of
Sm 857 but it may be related to an inhibitory effect on the release of mediators or on some earlier stage. Therefore investigation was carried out into its inhibitory action on
dextran- and
compound 48/80-induced
edema of the rat hind paw. As a result,
Sm 857 showed a stronger inhibitory effect on
dextran edema than
tranilast.
Sm 857 inhibited
endotoxin-induced
diarrhea in mice and the effect was similar to that of
tranilast, suggesting its inhibitory action on the release of mediators.