Abstract |
The specificity of CTL generated against tumors induced by murine leukemia viruses (MuLV) has been reported to parallel the expression of two serologically defined tumor cell surface antigens--the cross-reactive FMR antigen expressed on the surface of tumors induced by Friend, Moloney, and Rauscher MuLV, and the Gross cell surface antigen (GCSA) expressed on tumors induced by AKV/Gross MuLV. We examined the specificity of CTL generated against MuLV-induced tumors and identified two distinct patterns of reactivity. The first follows the traditional pattern of FMR vs GCSA reactivity as assessed on a panel of established MuLV-induced lymphomas. However, CTL exhibiting this pattern of reactivity are incapable of lysing MuLV-infected fibroblasts. CTL exhibiting the second pattern of reactivity are capable of lysing MuLV-induced lymphomas as well as MuLV-infected fibroblasts. In addition, these CTL exhibit extensive cross-reactivity between lymphomas and fibroblasts infected by both groups of MuLV. Our results suggest that CTL exhibiting the traditional FMR vs GCSA pattern of reactivity are directed against a tumor-associated antigen and not against virus-encoded antigens, and that CTL directed against MuLV-encoded antigens demonstrate extensive cross-reactivity, including the ability to lyse AKV-infected cells.
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Authors | D C Flyer, S J Burakoff, D V Faller |
Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 137
Issue 12
Pg. 3968-72
(Dec 15 1986)
ISSN: 0022-1767 [Print] United States |
PMID | 3491152
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antigens, Neoplasm
- Antigens, Viral
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Topics |
- AKR murine leukemia virus
(immunology)
- Animals
- Antigens, Neoplasm
(immunology)
- Antigens, Viral
(immunology)
- Cross Reactions
- Female
- Fibroblasts
(immunology)
- Friend murine leukemia virus
(immunology)
- Leukemia, Experimental
(immunology)
- Mice
- Mice, Inbred C57BL
- Moloney murine leukemia virus
(immunology)
- Rauscher Virus
(immunology)
- T-Lymphocytes, Cytotoxic
(immunology)
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