Current practice and evolving concepts in septic shock resuscitation.

Abstract

Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. Even though large randomized, controlled trials have addressed fundamental aspects of septic shock resuscitation, many questions still exist. In this review, we will describe the current standards of septic shock resuscitation, but the emphasis will be placed on evolving concepts in different domains such as clinical resuscitation targets, adequate use of fluids and vasoactive drugs, refractory shock, and the use of extracorporeal therapies. Multiple research opportunities remain open, and collaborative endeavors should be performed to fill in these gaps.

• Authors: Jan Bakker, Eduardo Kattan, Djillali Annane, Ricardo Castro, Maurizio Cecconi, Daniel De Backer, Arnaldo Dubin, Laura Evans, Michelle Ng Gong, Olfa Hamzaoui, Can Ince, Bruno Levy, Xavier Monnet, Gustavo A Ospina Tascón, Marlies Ostermann, Michael R Pinsky, James A Russell, Bernd Saugel, Thomas W L Scheeren, Jean-Louis Teboul, Antoine Vieillard Baron, Jean-Louis Vincent, Fernando G Zampieri, Glenn Hernandez
• Journal: Intensive care medicine (Intensive Care Med) Vol. 48 Issue 2 Pg. 148-163 (Feb 2022) ISSN: 1432-1238 [Electronic] United States
• PMID: 34910228 (Publication Type: Journal Article, Review)
• Copyright: © 2021. Springer-Verlag GmbH Germany, part of Springer Nature.

Topics

• Fluid Therapy
• Humans
• Resuscitation
• Shock, Septic