Abstract |
Ten patients cured of cryptococcosis and 14 normal volunteers were immunized with subcutaneous injections of cryptococcal polysaccharide (CPS). Peripheral mononuclear cells cultured from the volunteers 7 days post-immunization secreted significant amounts of IgM, IgA and IgG antibody to CPS in vitro. In cell cultures obtained 7 days after immunization of patients, nine of 10 had neither IgM nor IgG antibody response to CPS, and eight lacked anti-CPS IgA. Depletion of T lymphocytes from patients' cell cultures did not promote specific antibody secretion to CPS by B cells. The intense, prolonged antigenaemia with CPS that accompanies cryptococcosis may be responsible for the failure of cured patients to have circulating anti-CPS-secreting cells after immunization.
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Authors | D K Henderson, V L Kan, J E Bennett |
Journal | Clinical and experimental immunology
(Clin Exp Immunol)
Vol. 65
Issue 3
Pg. 639-46
(Sep 1986)
ISSN: 0009-9104 [Print] England |
PMID | 3490942
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Fungal
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Polysaccharides
- cryptococcal polysaccharide
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Topics |
- Adult
- Aged
- Antibodies, Fungal
(biosynthesis)
- B-Lymphocytes
(immunology)
- Cryptococcosis
(immunology)
- Humans
- Immune Tolerance
- Immunoglobulin A
(biosynthesis)
- Immunoglobulin G
(biosynthesis)
- Immunoglobulin M
(biosynthesis)
- Middle Aged
- Polysaccharides
(immunology)
- Rosette Formation
- T-Lymphocytes
(immunology)
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