Multicenter randomized phase II trial of atezolizumab with or without cobimetinib in biliary tract cancers.

Abstract

BACKGROUNDMEK inhibitors have limited activity in biliary tract cancers (BTCs) as monotherapy but are hypothesized to enhance responses to programmed death ligand 1 (PD-L1) inhibition.METHODSThis open-label phase II study randomized patients with BTC to atezolizumab (anti-PD-L1) as monotherapy or in combination with cobimetinib (MEK inhibitor). Eligible patients had unresectable BTC with 1 to 2 lines of prior therapy in the metastatic setting, measurable disease, and Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 1. The primary endpoint was progression-free survival (PFS).RESULTSSeventy-seven patients were randomized and received study therapy. The trial met its primary endpoint, with a median PFS of 3.65 months in the combination arm versus 1.87 months in the monotherapy arm (HR 0.58, 90% CI 0.35-0.93, 1-tail P = 0.027). One patient in the combination arm (3.3%) and 1 patient in the monotherapy arm (2.8%) had a partial response. Combination therapy was associated with more rash, gastrointestinal events, CPK elevations, and thrombocytopenia. Exploratory analysis of tumor biopsies revealed enhanced expression of antigen processing and presentation genes and an increase in CD8/FoxP3 ratios with combination treatment. Patients with higher baseline or lower fold changes in expression of certain inhibitory ligands (LAG3, BTLA, VISTA) on circulating T cells had evidence of greater clinical benefit from the combination.CONCLUSIONThe combination of atezolizumab plus cobimetinib prolonged PFS as compared with atezolizumab monotherapy, but the low response rate in both arms highlights the immune-resistant nature of BTCs.TRIAL REGISTRATIONClinicalTrials.gov NCT03201458.FUNDINGNational Cancer Institute (NCI) Experimental Therapeutics Clinical Trials Network (ETCTN); F. Hoffmann-La Roche, Ltd.; NCI, NIH (R01 CA228414-01 and UM1CA186691); NCI's Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancers (P50 CA062924); NIH Center Core Grant (P30 CA006973); and the Passano Foundation.

• Authors: Mark Yarchoan, Leslie Cope, Amanda N Ruggieri, Robert A Anders, Anne M Noonan, Laura W Goff, Lipika Goyal, Jill Lacy, Daneng Li, Anuj K Patel, Aiwu R He, Ghassan K Abou-Alfa, Kristen Spencer, Edward J Kim, S Lindsey Davis, Autumn J McRee, Paul R Kunk, Subir Goyal, Yuan Liu, Lauren Dennison, Stephanie Xavier, Aditya A Mohan, Qingfeng Zhu, Andrea Wang-Gillam, Andrew Poklepovic, Helen X Chen, Elad Sharon, Gregory B Lesinski, Nilofer S Azad
• Journal: The Journal of clinical investigation (J Clin Invest) Vol. 131 Issue 24 (12 15 2021) ISSN: 1558-8238 [Electronic] United States
• PMID: 34907910 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal, Humanized
• Azetidines
• Piperidines
• atezolizumab
• cobimetinib

Topics

• Aged
• Antibodies, Monoclonal, Humanized (administration & dosage, adverse effects)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Azetidines (administration & dosage, adverse effects)
• Biliary Tract Neoplasms (drug therapy, mortality)
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• Piperidines (administration & dosage, adverse effects)
• Progression-Free Survival