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Syntheses and effects of [Glu34]-thymopoietin II fragment 32-45 and its analogs on the impaired T-cell transformation in a patient with common variable immunodeficiency.

Abstract
[Glu34]-thymopoietin II fragment 32-45 and its three analogs were prepared by substitution of the amino acid residue at position 37. These peptides were synthesized by a conventional solution method, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid in the presence of m-cresol. These peptides were tested for their effects on impaired T-cell transformation by phytohemagglutinin in the common variable immunodeficiency. The relative potency of the synthetic [Glu34]-thymopoietin II fragment 32-45 was one-half of that of synthetic thymopoietin II fragment 32-45. Among these tetradecapeptide analogs, one analog in which Val37 was replaced by Ile exhibited a potent activity which was more than that of the synthetic [Glu34]-thymopoietin II fragment 32-45. The relative potencies of Thr37 and Tyr37 analogs were one-third and one-half, respectively of that of the synthetic [Glu34]-thymopoietin II fragment 32-45.
AuthorsT Abiko, H Shishido, H Sekino
JournalBiotechnology and applied biochemistry (Biotechnol Appl Biochem) 1986 Apr-Jun Vol. 8 Issue 2-3 Pg. 160-71 ISSN: 0885-4513 [Print] United States
PMID3488750 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Peptide Fragments
  • Thymopoietins
  • Thymus Hormones
Topics
  • Amino Acid Sequence
  • Cells, Cultured
  • Humans
  • Immunologic Deficiency Syndromes (immunology)
  • Lymphocyte Activation (drug effects)
  • Optical Rotation
  • Peptide Fragments (pharmacology)
  • Structure-Activity Relationship
  • T-Lymphocytes (drug effects, immunology)
  • Thymopoietins (chemical synthesis, pharmacology)
  • Thymus Hormones (pharmacology)

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