HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pharmacological study of the new mucolytic drug N-guanyl-cysteine.

Abstract
The pharmacological evaluation of N-guanyl-cysteine (IQB-782) is reported. This new cysteine derivative shows a potent mucolytic-expectorant activity in different test systems. Thus, IQB-782 protects rats against tobacco-smoke-induced respiratory airway obstruction, increases the tracheo-bronchial mucus secretion in rabbits and increases the pulmonary excretion of fluorescein in mice, an index of broncho-secretagogue activity. Like other mucolytics, IQB-782 is also effective in vitro in reducing the viscosity of a suspension of gastric mucin. This new drug is apparently devoid of any cardiovascular or autonomic activity and shows a moderate CNS depressant effect. IQB-782 is consequently a new thiol derivative which may offer some advantages in the treatment of different types of obstructive pulmonary disease.
AuthorsR Moratalla, R Romera, A Galiano
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 6 Pg. 918-23 (Jun 1986) ISSN: 0004-4172 [Print] Germany
PMID3488747 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Expectorants
  • N-guanylcysteine
  • Cysteine
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Bronchitis (etiology, physiopathology)
  • Cysteine (analogs & derivatives, pharmacology)
  • Expectorants (pharmacology)
  • Guinea Pigs
  • Hemodynamics (drug effects)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Psychomotor Performance (drug effects)
  • Rabbits
  • Rats
  • Rats, Inbred Strains
  • Sleep (drug effects)
  • Viscosity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: