Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies.

Abstract

INTRODUCTION:

It is not well established to use vitamin D supplementation for migraine, and this meta-analysis aims to explore the efficacy of vitamin D for migraine patients.

METHODS:

PubMed, EMbase, Web of science, EBSCO and Cochrane library databases were systematically searched up to May 2021, and we included randomized controlled trials (RCTs) exploring the effect of vitamin D for migraine patients.

RESULTS:

Six RCTs and 301 patients were included in the meta-analysis. Compared with control group in migraine patients, vitamin D supplementation could remarkably decrease headache attacks per month (MD = -2.74; 95% CI = -3.82 to -1.67; P < 0.00001), headache days per month (MD = -1.56; 95% CI = -2.44 to -0.68; P = 0.0005) and MIDAS score (MD = -5.72; 95% CI = -10.90 to -0.54; P = 0.03), but demonstrated no obvious influence on attack duration (MD = -2.20; 95% CI = -7.38 to 2.97; P = 0.40) or headache severity (MD = -0.56; 95% CI = -1.18 to 0.06; P = 0.08).

CONCLUSIONS:

Vitamin D supplementation provided additional benefits to treat migraine.

• Authors: Chen Hu, Yilin Fan, Shaoping Wu, Yu Zou, Xiaosu Qu
• Journal: The American journal of emergency medicine (Am J Emerg Med) Vol. 50 Pg. 784-788 (12 2021) ISSN: 1532-8171 [Electronic] United States
• PMID: 34879503 (Publication Type: Journal Article, Meta-Analysis, Review)
• Copyright: Copyright © 2021. Published by Elsevier Inc.

Chemical References

• Vitamins
• Vitamin D

Topics

• Dietary Supplements
• Humans
• Migraine Disorders (drug therapy, prevention & control)
• Randomized Controlled Trials as Topic
• Treatment Outcome
• Vitamin D (therapeutic use)
• Vitamins (therapeutic use)