Abstract | BACKGROUND: Current genetic association studies have reported conflicting results regarding the association between miRNA polymorphisms and myocardial infarction (MI) risk METHODS: Relevant studies were retrieved from the PubMed, EMBASE, ISI Web of Science, and Scopus databases. Eligible studies determining the association between miRNA polymorphisms and MI susceptibility were included and a meta-analysis was performed to quantify the associations between miRNA polymorphisms and MI risk. RESULTS: A total of eight studies with 2507 MI patients and 3796 healthy controls were included, dealing with nine miRNA genes containing 11 different loci, including miR-149 (rs71428439 and rs2292832), miR-126 (rs4636297 and rs1140713), miR-146a (rs2910164), miR-218 (rs11134527), miR-196a2 (rs11614913), miR-499 (rs3746444), miR-27a (rs895819), miR-26a‑1 (rs7372209), and miR-100 (rs1834306). miR-146a rs2910164 and miR-499 rs3746444 were determined to have a significant association with MI susceptibility, a finding that was supported by the meta-analysis (rs2910164: GG/CC, odds ratio [OR]: 1.40, 95% confidence interval [95% CI]: 1.05-1.74, p < 0.001; rs3746444: AA + AG/GG, OR = 2.04, 95% CI: 1.37-2.70, p < 0.001). Limited or conflicting data were found for the relationship between the other miRNA polymorphisms (rs71428439, rs4636297, rs1140713, rs11134527, rs11614913, rs895819, rs7372209, rs1834306, rs2292832) and MI risk. CONCLUSION: There was a significant association between rs2910164 and rs3746444 and MI susceptibility. Further studies are required to investigate the role of miRNA polymorphisms in MI risk.
|
Authors | Yang Yang, Xiajun Shi, Zhengxun Du, Gendong Zhou, Xiaohong Zhang |
Journal | Herz
(Herz)
Vol. 47
Issue 6
Pg. 524-535
(Dec 2022)
ISSN: 1615-6692 [Electronic] Germany |
Vernacular Title | Zusammenhang zwischen genetischen Varianten der Mikro-RNA und der Anfälligkeit für einen Herzinfarkt: Metaanalyse und systematische Übersicht. |
PMID | 34878577
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
|
Copyright | © 2021. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. |
Chemical References |
- MicroRNAs
- MIRN149 microRNA, human
- MIRN218 microRNA, human
|
Topics |
- Humans
- Genetic Association Studies
- Genetic Predisposition to Disease
(genetics)
- MicroRNAs
(genetics)
- Myocardial Infarction
(genetics)
- Polymorphism, Single Nucleotide
(genetics)
|