Abstract | BACKGROUND: METHODS: We explored whether tryptophan, kynurenine, and the ratio of kynurenine to tryptophan (KTR) in pre-diagnostic blood samples was related to risk of glioma in a nested case-control study of 84 cases and 168 matched controls from two cohort studies - the Nurses' Health Study, and the Health Professionals Follow-Up Study. Tryptophan and kynurenine were measured by liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were used to estimate risk ratios (RRs) and 95% confidence intervals (95%CI) for the associations between tertiles of these analytes and glioma risk. RESULTS: We observed no significant associations for either analyte or the ratio for risk of glioma overall. The RR for the highest KTR tertile compared to the lowest for all gliomas was 0.74 (95% CI: 0.34-1.59). All results were essentially unchanged in lagged analyses excluding the first two or four years of follow up, though data were sparse. CONCLUSION: Our findings do not provide support for an association between pre-diagnostic circulating KTR and risk of glioma.
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Authors | Claudine M Samanic, Yiyang Yue, David J Cote, Meir J Stampfer, Molin Wang, Adrian McCann, Øivind Midttun, Per Magne Ueland, Stephanie A Smith-Warner, Kathleen M Egan |
Journal | Cancer epidemiology
(Cancer Epidemiol)
Vol. 76
Pg. 102075
(02 2022)
ISSN: 1877-783X [Electronic] Netherlands |
PMID | 34871928
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2021 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Case-Control Studies
- Follow-Up Studies
- Glioma
(diagnosis)
- Humans
- Kynurenine
(metabolism)
- Prospective Studies
- Tryptophan
(metabolism)
- Tumor Microenvironment
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