Spurious sulfamethoxazole-trimethoprim resistance of Salmonella typhi.

Abstract

Several studies have identified thymidine excess in susceptibility test media as the cause of spurious resistance of various bacteria to sulfamethoxazole-trimethoprim. We document the phenomenon in Salmonella typhi and Salmonella paratyphi-A and demonstrate its occurrence in 3 of 17 (18%) lots of Mueller-Hinton agars now in use in major medical laboratories in Lima, Peru. The findings are particularly significant because sulfamethoxazole-trimethoprim is an important alternative to chloramphenicol or ampicillin for the treatment of typhoid and paratyphoid fevers.

• Authors: J Escamilla, M E Kilpatrick, H F Ugarte
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 23 Issue 1 Pg. 205-6 (Jan 1986) ISSN: 0095-1137 [Print] United States
• PMID: 3486190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Anti-Bacterial Agents
• Culture Media
• Drug Combinations
• Trimethoprim, Sulfamethoxazole Drug Combination
• Trimethoprim
• Sulfamethoxazole

Topics

• Anti-Bacterial Agents (pharmacology)
• Culture Media
• Drug Combinations (pharmacology)
• Drug Resistance, Microbial
• Microbial Sensitivity Tests
• Salmonella paratyphi A (drug effects)
• Salmonella typhi (drug effects)
• Sulfamethoxazole (pharmacology)
• Trimethoprim (pharmacology)
• Trimethoprim, Sulfamethoxazole Drug Combination