RIFM fragrance ingredient safety assessment, β-caryophyllene, CAS Registry Number 87-44-5.

Abstract

The existing information supports the use of this material as described in this safety assessment. β-Caryophyllene was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that β-caryophyllene is not genotoxic. Data on β-caryophyllene provided a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and fertility endpoints. The developmental and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to β-caryophyllene is below the TTC (0.03 mg/kg/day and 1.4 mg/day, respectively. Data show that there are no safety concerns for β-caryophyllene for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on data and ultraviolet/visible (UV/Vis) spectra; β-caryophyllene is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; β-caryophyllene was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

• Authors: A M Api, D Belsito, D Botelho, M Bruze, G A Burton Jr, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 159 Suppl 1 Pg. 112707 (Jan 15 2022) ISSN: 1873-6351 [Electronic] England
• PMID: 34848252 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Perfume
• Polycyclic Sesquiterpenes
• caryophyllene

Topics

• Academies and Institutes (standards)
• Animals
• Dermatitis, Photoallergic
• Dermatitis, Phototoxic
• Endpoint Determination
• Environmental Exposure (adverse effects)
• Europe
• Fertility (drug effects)
• Humans
• Mutagenicity Tests
• North America
• Odorants (analysis)
• Perfume (chemistry, toxicity)
• Plants, Edible (chemistry)
• Polycyclic Sesquiterpenes (analysis, toxicity)
• Quantitative Structure-Activity Relationship
• Registries
• Reproduction (drug effects)
• Respiratory System (drug effects)
• Risk Assessment
• Safety
• Skin (drug effects)
• Toxicity Tests