Abstract |
Preliminary studies related to immunotoxicologic effects of 2,5-hexanedione, the final major metabolite of n-hexane/MnBk, were carried out in rats following single or repeated exposures. Female albino rats were given either single or seven consecutive oral doses of 0.1, 0.2, or 0.5 X LD50 of 2,5-hexanedione, and a time-related kinetic study was performed using hematology, histology, cellularity, and organ weight/ body weight as major parameters. Following single exposure of 2,5-hexanedione to rats, a dose-dependent thymic atrophy was evident at the end of 7 days. The atrophy was reversible when the animals were given 7 days nonexposure rest. In contrast, there was no thymic atrophy when the animals were exposed for 7 consecutive days. Significant decline in the cellular populations of various lymphoid organs was also observed in rats exposed either to single or repeated doses of 2,5-hexanedione. Results obtained in the present study indicate that 2,5-hexanedione, a known potent neurotoxic substance, adversely affects the lymphoid organs of the immune system in rats.
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Authors | R K Upreti, K P Singh, A K Saxena, R Shanker |
Journal | Environmental research
(Environ Res)
Vol. 39
Issue 1
Pg. 188-98
(Feb 1986)
ISSN: 0013-9351 [Print] Netherlands |
PMID | 3484701
(Publication Type: Journal Article)
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Chemical References |
- Hexanones
- Ketones
- 2,5-hexanedione
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Topics |
- Animals
- Cell Count
(drug effects)
- Cell Survival
(drug effects)
- Female
- Hexanones
(toxicity)
- In Vitro Techniques
- Ketones
(toxicity)
- Lethal Dose 50
- Lymph Nodes
(drug effects, pathology)
- Lymphoid Tissue
(drug effects, pathology)
- Organ Size
(drug effects)
- Rats
- Spleen
(drug effects, pathology)
- T-Lymphocytes
(drug effects, pathology)
- Thymus Gland
(drug effects, pathology)
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