Abstract |
Among 46 patients with chronic lymphocytic leukemia (CLL) (40 B cell, 6 T cell) and 40 patients with cutaneous T cell lymphoma (CTCL), a chromosomally abnormal neoplastic clone was identified in 43 cases. A translocation involving 14q32 was present in nine cases (five B-CLL, two T-CLL, two CTCL). The donor chromosomal site was 11q13 in four patients and 1q12, 4q25-27, 17q21-22, 18q21, and 22q11 in one case each. The next most frequent abnormalities were rearrangements involving 6q21-23 (four cases), and trisomy 12 (four cases, all B-CLL). In one CTCL patient, the t(11;14) translocation was present in one of three apparently unrelated T cell clones. Recent studies indicate that the selective advantage conferred by the 14q+ chromosome in B cell neoplasms appears to result from an oncogene being brought adjacent to a rearranged and transcriptionally active immunoglobulin heavy chain locus. The present findings suggest that similar mechanisms may operate in certain T cell neoplasms, although the activating gene is not necessarily the same.
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Authors | P C Nowell, E C Vonderheid, E Besa, J A Hoxie, L Moreau, J B Finan |
Journal | Cancer genetics and cytogenetics
(Cancer Genet Cytogenet)
Vol. 19
Issue 3-4
Pg. 219-27
(Jan 15 1986)
ISSN: 0165-4608 [Print] United States |
PMID | 3484667
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Aged
- B-Lymphocytes
- Chromosomes, Human, 1-3
- Chromosomes, Human, 13-15
- Humans
- Leukemia, Lymphoid
(genetics)
- Lymphoma
(genetics)
- Male
- Sezary Syndrome
(genetics)
- Skin Neoplasms
(genetics)
- T-Lymphocytes
- Translocation, Genetic
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