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The most common chromosome change in 86 chronic B cell or T cell tumors: a 14q32 translocation.

Abstract
Among 46 patients with chronic lymphocytic leukemia (CLL) (40 B cell, 6 T cell) and 40 patients with cutaneous T cell lymphoma (CTCL), a chromosomally abnormal neoplastic clone was identified in 43 cases. A translocation involving 14q32 was present in nine cases (five B-CLL, two T-CLL, two CTCL). The donor chromosomal site was 11q13 in four patients and 1q12, 4q25-27, 17q21-22, 18q21, and 22q11 in one case each. The next most frequent abnormalities were rearrangements involving 6q21-23 (four cases), and trisomy 12 (four cases, all B-CLL). In one CTCL patient, the t(11;14) translocation was present in one of three apparently unrelated T cell clones. Recent studies indicate that the selective advantage conferred by the 14q+ chromosome in B cell neoplasms appears to result from an oncogene being brought adjacent to a rearranged and transcriptionally active immunoglobulin heavy chain locus. The present findings suggest that similar mechanisms may operate in certain T cell neoplasms, although the activating gene is not necessarily the same.
AuthorsP C Nowell, E C Vonderheid, E Besa, J A Hoxie, L Moreau, J B Finan
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 19 Issue 3-4 Pg. 219-27 (Jan 15 1986) ISSN: 0165-4608 [Print] United States
PMID3484667 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Topics
  • Aged
  • B-Lymphocytes
  • Chromosomes, Human, 1-3
  • Chromosomes, Human, 13-15
  • Humans
  • Leukemia, Lymphoid (genetics)
  • Lymphoma (genetics)
  • Male
  • Sezary Syndrome (genetics)
  • Skin Neoplasms (genetics)
  • T-Lymphocytes
  • Translocation, Genetic

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