Comparison of survival outcomes of abdominal radical hysterectomy and radiochemotherapy IIA2 (FIGO2018) cervical cancer: a retrospective study from a large database of 63,926 cases of cervical cancer in China.

Abstract

AIM:

This study aimed to compare the 5-year overall survival (OS) and 5-year DFS disease-free survival (DFS) of abdominal radical hysterectomy (ARH) and radiochemotherapy (R-CT) for stage IIA2 (FIGO 2018) cervical cancer patients.

METHODS:

Based on this multicenter, retrospective cohort study based on data from the clinical diagnosis and treatment of cervical cancer in China (Four C) database, 609 cases with 2018 FIGO stage IIA2 cervical cancer from 2004 to 2018 were reviewed. The 5-year OS and 5-year DFS of patients with either of the two treatment methods were compared by means of a multivariate Cox regression model and the log-rank method in the total study population and after propensity score matching (PSM).

RESULTS:

We selected 609 of 63,926 patients and found that R-CT was associated with a significantly worse 5-year OS (71.8% vs. 95.3%, P < 0.001; hazard ratio (HR) = 6.596, 95% CI 3.524-12.346) and 5-year DFS (69.4% vs. 91.4%, P < 0.001; HR = 4.132, 95% CI 2.570-6.642, P < 0.001) than ARH in the total study population. After matching (n = 230/230), among FIGO 2018 IIA2 patients, the 5-year OS and DFS were lower in the R-CT group than in the ARH group (OS: 73.9% vs. 94.7%, P < 0.001; HR = 5.633, 95% CI 2.826-11.231, P < 0.001; DFS: 69.2% vs. 91.1%, P < 0.001; HR = 3.978, 95% CI 2.336-6.773, P < 0.001, respectively).

CONCLUSIONS:

In patients with stage FIGO 2018 IIA2 cervical cancer, ARH offers better 5-year OS and DFS outcomes than R-CT; however, due to the inherent biases of retrospective studies, this needs to be confirmed by randomized trials.

• Authors: Junshen He, Donglin Li, Ping Shen, Wentong Liang, Shan Kang, Yi Zhang, Hongwei Zhao, Mubiao Liu, Xiaohong Wang, Zhong Lin, Xiaonong Bin, Jinghe Lang, Ping Liu, Chunlin Chen
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 27 Issue 3 Pg. 619-625 (Mar 2022) ISSN: 1437-7772 [Electronic] Japan
• PMID: 34837596 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2021. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.

Topics

• Chemoradiotherapy
• China (epidemiology)
• Female
• Humans
• Hysterectomy (methods)
• Neoplasm Staging
• Retrospective Studies
• Uterine Cervical Neoplasms (pathology)