Multiple autoimmunity and epitope spreading in monozygotic twins.

Abstract

We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.

• Authors: Esperanza Avalos-Díaz, Elena Pérez-Pérez, Julio Granados, Deyanira Pacheco-Tovar, Juan-José Bollain-Y-Goytia-de-la-Rosa, Rafael Herrera-Esparza
• Journal: Journal of translational autoimmunity (J Transl Autoimmun) Vol. 4 Pg. 100132 ( 2021) ISSN: 2589-9090 [Electronic] Netherlands
• PMID: 34816112 (Publication Type: Journal Article)
• Copyright: © 2021 The Authors.