Antiproliferative response of human leukemic cells. Modulation of cytosolic protein kinase C activity by phytohemagglutinin.

Abstract

Phytohemagglutinin and its isolectins PHA-E4 an PHA-L4 act antiproliferatively on an actively dividing leukemia T-cell line. Both PHA and the isolectins caused an increase in soluble protein kinase C (PK-C) activity without a corresponding decrease in particulate activity. The increase was at a maximum after 10 min and the soluble kinase activity remained high for at least 3 h. There was no direct correlation between the observed antiproliferative potency of the 2 isolectins and their ability to initially affect the distribution of PK-C activity.

• Authors: C A Borrebaeck, J Bristulf, B Jergil
• Journal: Cancer letters (Cancer Lett) Vol. 38 Issue 1-2 Pg. 181-9 (Dec 1987) ISSN: 0304-3835 [Print] Ireland
• PMID: 3480041 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lectins
• Phytohemagglutinins
• Protein Kinase C

Topics

• Cell Division (drug effects)
• Dose-Response Relationship, Drug
• Humans
• Lectins (pharmacology)
• Leukemia, Lymphoid (enzymology)
• Phytohemagglutinins (pharmacology)
• Protein Kinase C (analysis)
• Tumor Cells, Cultured