Developmental milestones, problems with bladder and bowel control, sleep disturbances,
allergies, and handedness were compared in 247 consecutive
Tourette syndrome (TS) patients, 17 patients with
attention-deficit disorder (ADD), 15 patients with ADD secondary to TS (ADD 2(0) TS), and 47 random controls. There were no significant differences in age of first talking or walking. By contrast, there were significant differences in problems with bladder and bowel control between TS patients and controls, as measured by age of first toilet training, age of last bed-wetting, frequency of
enuresis, and age that bowel control was achieved. Sleep problems were pervasive in TS patients, with a significantly increased frequency of
sleepwalking,
night terrors, trouble getting to sleep,
early awakening, and inability to take afternoon
naps as a young child. In all diagnostic categories, including mild (grade 1) TS patients, a total sleep-problem score was significantly greater than that in controls. The
sleep disorders and other TS symptoms are consistent with TS as a disorder of disinhibition of the limbic system.
Allergies and left-handedness have been evoked as contributing to or being associated with ADD and
learning disorders. There were no significant differences in the frequency of
allergies or left-handedness in TS patients compared with that in controls. We conclude that when there is a clearly defined genetic cause of ADD and
learning disorders, it is not associated with an increased frequency of
allergies or left-handedness.