Abstract |
In oral surgery, tissue loss may occur in some cases, resulting in bone exposure and subsequent wound infection and possible scar formation during secondary healing. In this study, Terudermis® Artificial Dermis (AD-T), a dermal defect graft made from processed bovine dermis collagen and gelatin sponge (GS) were used as dressings on 100-mm2 wounds with exposed bone on the heads of rats. For the control group, the wound was left exposed. The wound-healing efficacy of the treatment was compared macroscopically and histologically among the three groups at 1, 2, and 4 weeks after surgery. Complete wound healing was achieved faster in the AD-T group than in the GS group, and osteoblasts appeared on the bone surface, indicating accelerated bone remodeling. Furthermore, in the AD-T group, there was an increased production of newly formed blood vessels, fibroblasts and osteoblasts positive for anti- cortactin antibodies, which are believed to contribute to wound healing. Our findings suggest that AD-T is better than GS as a wound dressing material.
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Authors | Yasuyuki Asada, Shinya Koshinuma, Masaki Mikami, Yuuki Shirai, Yoshisato Machida, Takahisa Nakayama, Ryoji Kushima, Gaku Yamamoto, Ken-Ichi Mukaisho |
Journal | Experimental animals
(Exp Anim)
Vol. 71
Issue 2
Pg. 161-172
(May 20 2022)
ISSN: 1881-7122 [Electronic] Japan |
PMID | 34789616
(Publication Type: Journal Article)
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Chemical References |
- atelocollagen
- Gelatin
- Collagen
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Topics |
- Animals
- Bandages
- Cattle
- Collagen
- Dermis
- Gelatin
- Rats
- Wound Healing
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