Genetic markers in late paraphrenia: a study of HLA antigens.

Abstract

Patients with late paraphrenia were typed for HLA-A, -B and -C. Increased frequencies of BW55 (P = 0.036), B37 (P = 0.008) and CW6 (P = 0.056) were found relative to controls. Unlike findings in paranoid schizophrenia, there was no HLA-A9 association, suggesting that paraphrenics may be genetically distinct from schizophrenics. The primary association seems to be with B37, which has the lowest corrected P value and highest relative risk; if this were replicated, it would make possession of this antigen a strong risk factor for developing the disorder.

• Authors: M Naguib, P McGuffin, R Levy, H Festenstein, A Alonso
• Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 150 Pg. 124-7 (Jan 1987) ISSN: 0007-1250 [Print] England
• PMID: 3477302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers
• HLA Antigens

Topics

• Aged
• Depressive Disorder, Major (genetics)
• Female
• Genetic Markers
• HLA Antigens (genetics)
• Humans
• Male
• Middle Aged