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Do endogenous lipoproteins modulate the sensibility of animals against arrhythmogenic drugs?

Abstract
The present study suggests that a diminished level of HDL is connected with an enhanced susceptibility to arrhythmogenic stimuli only in rats pretreated with a diet deficient in polyunsaturated fatty acids (PUFA), but not after a PUFA-rich or pellet diet. The endogenous level of total cholesterol did not influence the thresholds for ventricular flutter or ventricular fibrillation in aconitine-induced arrhythmia in rats or in ouabain-induced arrhythmia in guinea pigs.
AuthorsJ Beitz, S Schneider, A Riedel, H J Mest
JournalProstaglandins, leukotrienes, and medicine (Prostaglandins Leukot Med) Vol. 28 Issue 2 Pg. 215-20 (Jul 1987) ISSN: 0262-1746 [Print] Scotland
PMID3476969 (Publication Type: Journal Article)
Chemical References
  • Cholesterol, HDL
  • Fatty Acids, Unsaturated
  • Ouabain
  • Cholesterol
  • Aconitine
Topics
  • Aconitine (pharmacology)
  • Aconitum (analogs & derivatives)
  • Animals
  • Arrhythmias, Cardiac (chemically induced, physiopathology)
  • Cholesterol (blood)
  • Cholesterol, HDL (blood)
  • Fatty Acids, Unsaturated (deficiency, pharmacology)
  • Guinea Pigs
  • Ouabain (pharmacology)
  • Rats
  • Rats, Inbred Strains

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