Induction of acetylated low density lipoprotein receptor and suppression of low density lipoprotein receptor on the cells of human monocytic leukemia cell line (THP-1 cell).

Abstract

THP-1 cells, a human cell line established from acute monocytic leukemia cells, degraded native human low density lipoprotein (LDL) through a LDL-specific pathway, but had no ability to degrade acetylated LDL. When the cells were treated with 12-o-tetradecanoyl-phorbol-13-acetate (TPA) to differentiate into the macrophage-like stage, those acquired the ability to degrade acetylated LDL through its specific pathway and lost the ability to degrade native LDL. Degradation of acetylated LDL by the differentiated cells was not reduced by preincubation with either acetylated LDL or native LDL.

• Authors: H Hara, H Tanishita, S Yokoyama, S Tajima, A Yamamoto
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 146 Issue 2 Pg. 802-8 (Jul 31 1987) ISSN: 0006-291X [Print] United States
• PMID: 3476117 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cell Adhesion Molecules
• Lipoproteins, LDL
• Receptors, LDL
• Receptors, Scavenger

Topics

• Cell Adhesion Molecules
• Cell Line
• Humans
• Leukemia, Myeloid (metabolism)
• Lipoproteins, LDL (metabolism)
• Receptors, LDL (metabolism)
• Receptors, Scavenger