Abstract | AIM: METHODS: Of the 261 enrolled gastric cancer patients, 164 patients were diagnosed with osteoporosis based on criteria of the Japan Society of Osteoporosis. They were randomly assigned 1:1 to groups treated with active vitamin D (VD group) or monthly minodronate (MIN group). The primary endpoint was changes in lumbar bone mineral density (L-BMD) 12 mo after the start of administration. The secondary endpoints were changes in bone metabolism markers, adverse events (AEs), or treatment completion rates. RESULTS: There was no significant difference in patient background between the VD (n = 82) and MIN (n = 82) groups. In the MIN group, the increase in L-BMD was significantly higher than that in the VD group (4.52% vs 1.72%, P = .001), with a significant reduction in bone metabolism markers; blood NTX (-25.6% vs -1.6%, P < .01) and serum bone-specific alkaline phosphatase (-34.3% vs -20.1%, P < .01). AEs were observed in 26.8% and 9.3% of the patients and treatment completion rates were 77.5% and 89.3% in the MIN and VD groups, respectively. Serious AEs were not observed in either group. CONCLUSION:
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Authors | Masashi Hirota, Tsuyoshi Takahashi, Yurina Saito, Ryohei Kawabata, Rie Nakatsuka, Hiroshi Imamura, Masaaki Motoori, Yoichi Makari, Atsushi Takeno, Kentaro Kishi, Shinichi Adachi, Hiromichi Miyagaki, Yukinori Kurokawa, Makoto Yamasaki, Hidetoshi Eguchi, Yuichiro Doki |
Journal | Annals of gastroenterological surgery
(Ann Gastroenterol Surg)
Vol. 5
Issue 6
Pg. 754-766
(Nov 2021)
ISSN: 2475-0328 [Electronic] Japan |
PMID | 34755007
(Publication Type: Journal Article)
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Copyright | © 2021 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology. |