Inability of fructose 1,6-diphosphate to reduce myocardial infarct size.

Abstract

Fructose 1,6-diphosphate has been reported to reduce ischemic damage following coronary artery occlusion. To further evaluate fructose 1,6-diphosphate, we studied its effect on myocardial infarct size in open-chest, anesthetized dogs. Twenty min following left anterior descending coronary artery ligation, the animals received a constant infusion of either normal saline or fructose 1,6-diphosphate. Six hours following coronary artery ligation, the animals were killed and the hearts were sectioned from base to apex. Area at risk, infarct size, and infarct size expressed as a percentage of the area at risk were determined. Fructose 1,6-diphosphate had no effect on the amount of necrosis following coronary artery ligation. The area of necrosis expressed as a percentage of the left ventricle was similar in control (26 +/- 3%) and treated groups (24 +/- 4%). The area of necrosis expressed as a percentage of the area at risk was also similar in control and treated groups. Thus, in this model of myocardial ischemia, fructose 1,6-diphosphate does not reduce myocardial infarct size.

• Authors: E J Brown Jr, L Erburu, R A Kloner
• Journal: Journal of medicine (J Med) Vol. 18 Issue 1 Pg. 43-53 ( 1987) ISSN: 0025-7850 [Print] United States
• PMID: 3474341 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fructosediphosphates
• Hexosediphosphates
• fructose-1,6-diphosphate

Topics

• Animals
• Dogs
• Fructosediphosphates (therapeutic use)
• Hexosediphosphates (therapeutic use)
• Myocardial Infarction (drug therapy)