Abstract | BACKGROUND: METHODS: We first achieved favorable properties as a potential anti- tumor agent. We then compared cell viability and cisplatin uptake in chemoresistant NSCLC cells before and after the use of 2D Ti2 C. Afterwards, we explored the effects of 2D Ti2 C on intracellular antioxidant reserves, followed by evaluating the subsequent changes in the expression of core drug resistance genes. Finally, we confirmed the tumor inhibitory effect and bio-safety of 2D Ti2 C in a drug-resistant lung cancer model in nude mice. RESULTS: CONCLUSIONS: 2D Ti2 C can reverse NSCLC chemoresistance both in vitro and in vivo, suggesting that it may potentially become a novel and effective means to treat chemoresistant NSCLC in the clinic.
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Authors | Yue Zhu, Baiyan Sui, Xin Liu, Jiao Sun |
Journal | Thoracic cancer
(Thorac Cancer)
Vol. 12
Issue 24
Pg. 3340-3355
(12 2021)
ISSN: 1759-7714 [Electronic] Singapore |
PMID | 34741403
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Antineoplastic Agents
- Antioxidants
- titanium carbide
- Titanium
- Cisplatin
|
Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Antioxidants
(metabolism)
- Apoptosis
(drug effects)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cisplatin
(pharmacology)
- Drug Resistance, Neoplasm
(drug effects)
- Female
- Humans
- Lung Neoplasms
(drug therapy)
- Mice
- Mice, Nude
- Titanium
(pharmacology)
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