Sodium valproate (Epilim) in the treatment of refractory epilepsy.

Abstract

Sodium valproate was given to seven children with refractory epilepsy and mental retardation. Four of the children became fit free while another was much improved. Plasma levels of sodium valproate correlated well with the dose prescribed and did not approach the theoretical top-desirable level of 200 microgram/ml despite larger than recommended doses. Side effects were minimal and it is concluded that the drug is safe and useful.

• Authors: D R Lines
• Journal: The New Zealand medical journal (N Z Med J) Vol. 87 Issue 603 Pg. 9-12 (Jan 11 1978) ISSN: 0028-8446 [Print] New Zealand
• PMID: 347342 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Valerates
• Valproic Acid

Topics

• Adolescent
• Anticonvulsants (blood)
• Child
• Child, Preschool
• Drug Interactions
• Epilepsy (blood, drug therapy)
• Female
• Humans
• Male
• Valerates (therapeutic use)
• Valproic Acid (blood, therapeutic use)