Cytogenetic analysis of a gossypol-induced murine myxosarcoma.

Abstract

Cytogenetic analysis of gossypol acetate-induced murine myxosarcoma demonstrated a stemline of 78 chromosomes and the presence of three marker (M) chromosomes produced by robertsonian translocation. Tumor cells at passage 1 that contain chromosomes M1 and M2 were nontumorigenic, whereas cells at passage 3 were tumorigenic in syngeneic mice and showed M1, M2, and M3. The presence of M3 has been implicated to be responsible for the tumorigenic phenotype.

• Authors: M K Dhaliwal, J O Norman, S Pathak, D L Busbee
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 78 Issue 6 Pg. 1203-9 (Jun 1987) ISSN: 0027-8874 [Print] United States
• PMID: 3473256 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gossypol

Topics

• Animals
• Chromosomes
• Female
• Gossypol
• Karyotyping
• Male
• Mice
• Myxosarcoma (chemically induced, genetics)
• Sarcoma (genetics)
• Translocation, Genetic