Acute tumour lysis syndrome with extreme metabolic abnormalities.

Abstract

Tumour lysis syndrome, manifested by various metabolic derangements, is a known complication after treatment of some lymphoid malignancies. A patient is reported with acute lymphocytic leukaemia who developed a tumour lysis syndrome following intensive chemotherapy. All the known complications of the syndrome were present in the most severe form--hyperuricaemia of 1.44 mmol/l, hyperphosphataemia of 7.7 mmol/l with acute oliguric renal failure and extreme hyperkalaemia of 9.8 mmol/l with electrocardiographic changes. This life-threatening condition did not respond to conservative measures and the patient recovered only after haemodialysis.

• Authors: Y Leonov, A Golik, S Kaufman, Y Gilboa
• Journal: Clinical and laboratory haematology (Clin Lab Haematol) Vol. 9 Issue 1 Pg. 85-9 ( 1987) ISSN: 0141-9854 [Print] England
• PMID: 3472702 (Publication Type: Case Reports, Journal Article)

Chemical References

• Phosphates
• Uric Acid

Topics

• Adult
• Drug-Related Side Effects and Adverse Reactions
• Humans
• Hypercalcemia (complications)
• Hyperkalemia (complications)
• Hypocalcemia (complications)
• Leukemia, Lymphoid (complications, drug therapy)
• Male
• Paraneoplastic Syndromes (physiopathology)
• Phosphates (blood)
• Uric Acid (blood)