Synergistic effects of quaternary ammonium compounds and food additive grade calcium hydroxide on microbicidal activities at low temperatures.

Abstract

The microbicidal activities of mixtures of quaternary ammonium compounds (QACs) and food additive grade calcium hydroxide (FdCa(OH)2) were evaluated in a suspension test at -20°C using an anti-freeze agent (AFA) containing methanol, or at 1°C, with varying contact time, toward avian influenza virus (AIV), Newcastle disease virus (NDV), fowl adenovirus (FAdV), avian reovirus (ARV), Salmonella Infantis (SI) and Escherichia coli (EC). At -20°C, the mixtures could inactivate AIV and NDV within 30 min, FAdV and ARV within 5 sec, and SI and EC within 3 min, respectively. AFA did not inactivate viruses and bacteria within 30 min and 10 min, respectively. At 1°C, the mixtures inactivated FAdV and ARV within 30 sec, AIV within 10 min, and NDV within 30 min. A mixture of slaked lime (SL) and QAC could inactivate FAdV and ARV within 30 sec, but could not inactivate AIV and NDV even after 60 min at 1°C. SL could not substitute FdCa(OH)2 in order to exert the synergistic effects with QAC. Thus, QACs microbicidal activities were maintained or enhanced by adding FdCa(OH)2. It is hence recommended to use QACs with FdCa(OH)2, especially in the winter season.

• Authors: Md Humayun Kabir, Yu Miyaoka, Md Amirul Hasan, Makiko Yamaguchi, Dany Shoham, Harumi Murakami, Kazuaki Takehara
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 83 Issue 12 Pg. 1820-1825 (Dec 02 2021) ISSN: 1347-7439 [Electronic] Japan
• PMID: 34719533 (Publication Type: Journal Article)

Chemical References

• Disinfectants
• Food Additives
• Quaternary Ammonium Compounds
• Calcium Hydroxide

Topics

• Animals
• Calcium Hydroxide (pharmacology)
• Chickens
• Disinfectants
• Food Additives
• Influenza in Birds
• Newcastle disease virus
• Quaternary Ammonium Compounds (pharmacology)
• Temperature