Abstract |
Raman spectroscopy coupled with confocal microscopy offers an alternative bioimaging technique overcoming limitations associated with sensitivity, tissue penetration and image resolution. Allied to the surface-enhanced Raman scattering (SERS) properties of gold nanoparticles (AuNP), we designed SERS nanoprobes with enhanced properties and straightforward application as bio-labelling agents for gliomas. The ensuing nanoprobes coated with simple sugar units ( galactose or glucose) allowed assessing information about their intracellular localization (vesicular structures), with impressive sensitivity towards complex environments and proved the ability to overcome biological auto-fluorescence and high penetration in tissues. We validate the use of sugars as an all-in-one vector (Raman reporter, conferring high stability, biocompatibility and affinity to glioma cells) as imaging agents using an impressive technique.
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Authors | Maria C Gomes, Juan Chen, Angela Cunha, Tito Trindade, Gang Zheng, João P C Tomé |
Journal | Journal of materials chemistry. B
(J Mater Chem B)
Vol. 9
Issue 45
Pg. 9285-9294
(11 24 2021)
ISSN: 2050-7518 [Electronic] England |
PMID | 34709285
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Galectins
- Monosaccharide Transport Proteins
- Gold
- Glucose
- Galactose
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Topics |
- Galactose
(chemistry, metabolism)
- Galectins
(genetics, metabolism)
- Glucose
(chemistry, metabolism)
- Gold
(chemistry)
- Metal Nanoparticles
(chemistry)
- Monosaccharide Transport Proteins
(genetics, metabolism)
- Spectrum Analysis, Raman
(methods)
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