[Fibrous dysplasia and ossifying fibroma. Morphologic criteria].

Abstract

Among a series of 42 ossifying fibromas and 32 fibrous dysplasias, 5 cases were studied by histoenzymological and electron microscopic methods. The histological study in 2/3 of cases is sufficient for the diagnosis between the two diseases: trabecular bone in a connective tissue with regular collagen fibres in the ossifying fibroma; nodular indented bony areas with irregular collagen frame in fibrous dysplasia. By histoenzymology, the diagnosis between the two affections is not easy: same activity of ATPases and alkaline phosphatases in fibroblasts and osteoblasts. By electron microscopy, the morphology of the two lesions is different: in ossifying fibroma, numerous well-differentiated osteoblasts and large areas of ossification are seen; in fibrous dysplasia, undifferentiated cells are numerous and the collagen frame is irregularly mineralized. This method is also useful for the histogenetic understanding of these two osteopathies.

• Authors: G Chomette, M Auriol, S Boisnic, F Guilbert, J M Vaillant
• Journal: Revue de stomatologie et de chirurgie maxillo-faciale (Rev Stomatol Chir Maxillofac) Vol. 88 Issue 1 Pg. 1-7 ( 1987) ISSN: 0035-1768 [Print] France
• Vernacular Title: Dysplasie fibreuse et fibrome ossifiant. Critères morphologiques.
• PMID: 3470881 (Publication Type: English Abstract, Journal Article)

Chemical References

• Collagen
• Oxidoreductases

Topics

• Collagen
• Diagnosis, Differential
• Facial Bones (enzymology, pathology, ultrastructure)
• Fibroblasts (pathology, ultrastructure)
• Fibroma (enzymology, pathology, ultrastructure)
• Fibrous Dysplasia of Bone (enzymology, pathology)
• Humans
• Mesoderm (cytology)
• Osteoblasts (pathology, ultrastructure)
• Osteocytes (pathology, ultrastructure)
• Osteoma (enzymology, pathology, ultrastructure)
• Oxidoreductases (metabolism)
• Skull Neoplasms (enzymology, pathology, ultrastructure)