Pharmacokinetic studies of imipenem/cilastatin in elderly patients.

Abstract

Six patients, aged between 68 and 83 years, with glomerular filtration rates (GFR) between 31 and 80 ml/min received imipenem/cilastatin as treatment for acute lower respiratory tract infection. A combination of 500 mg of both agents was administered, 6-hourly, intravenously over 30 min. After a minimum of four doses, blood specimens were obtained for assay of imipenem and cilastatin concentrations by HPLC. Pharmacokinetic parameters were calculated from the results. The mean half life was 1.6 h for imipenem and 2.1 h for cilastatin, values similar to those reported for patients with moderate renal impairment. Elimination constant, clearance and AUC significantly correlated with GFR but not with age. No accumulation was observed.

• Authors: R G Finch, C Craddock, J Kelly, N B Deaney
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 18 Suppl E Pg. 103-7 (Dec 1986) ISSN: 0305-7453 [Print] England
• PMID: 3469182 (Publication Type: Journal Article)

Chemical References

• Cyclopropanes
• Thienamycins
• Cilastatin
• Imipenem
• Dipeptidases

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Cilastatin
• Cyclopropanes (blood, metabolism)
• Dipeptidases (antagonists & inhibitors)
• Glomerular Filtration Rate
• Humans
• Imipenem
• Kinetics
• Thienamycins (blood, metabolism)