Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in
traditional medicine in the Amazon region. Studies of the
essential oil of this species have identified many
terpene compounds. However, little is known about the possible uses of
solid waste generated by the extraction of
essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the
essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of
sesquiterpenes and particularly sequiterpenic
ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the
enzyme arginase and proliferation of
cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro.