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Cytotoxic effects of free fatty acids on ascites tumor cells.

Abstract
The effect of physiologic common free fatty acids (FFAs) on Mat 1376b ascites tumor cells in vitro and in vivo in F344 rats was investigated. Unsaturated fatty acids, such as palmitoleic (16:1), oleic (18:1), linoleic (18:2), linolenic (18:3), and arachidonic (20:4) acids, were significantly more effective killers of tumor cells in vitro than the corresponding saturated fatty acids of the same carbon length, including palmitic (16:0), stearic (18:0), and arachidic (20:0) acids. The saturated 16-carbon fatty acid (palmitic acid) was more toxic to tumor cells in vitro than the saturated 18-carbon (stearic) and 20-carbon (arachidic) acids. Injections of linoleic (18:2)-linolenic (18:3) acid combinations into rats inoculated with the tumor significantly enhanced the survival of the tumor-bearing animals. These results suggest that natural FFAs may under certain conditions be utilized as effective anticancer agents.
AuthorsI Siegel, T L Liu, E Yaghoubzadeh, T S Keskey, N Gleicher
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 78 Issue 2 Pg. 271-7 (Feb 1987) ISSN: 0027-8874 [Print] United States
PMID3468290 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Fatty Acids, Nonesterified
Topics
  • Animals
  • Antineoplastic Agents
  • Ascitic Fluid
  • Cell Line
  • Fatty Acids, Nonesterified (pharmacology)
  • Female
  • In Vitro Techniques
  • Mammary Neoplasms, Experimental (drug therapy)
  • Rats
  • Rats, Inbred F344

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