Abstract |
In 5 patients with respiratory tract infections, concentrations of cefotetan (CTT) in serum and sputum after 1 hour intravenous administration of 2 g of CTT to each patient were investigated, and following results were obtained. Serum levels of CTT The mean peak level of CTT was 232.0 +/- 16.2 micrograms/ml immediately after the 1 hour drip infusion, then declined gradually and was 48.0 +/- 8.8 micrograms/ml after 6 hours. Sputum levels of CTT Mean sputum levels of CTT were 2.15 +/- 0.19 micrograms/ml from 2 to 4 hours after the administration and 2.19 +/- 0.18 micrograms/ml from 4 to 6 hours. Clinical evaluation of CTT Clinical effects were excellent in 1 case, good in 3 cases and poor in 1 case. No side effects were observed.
|
Authors | Y Matsumoto, Y Hitsuda, Y Sugimoto, J Ishikawa, T Sasaki |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 39
Issue 10
Pg. 2690-4
(Oct 1986)
ISSN: 0368-2781 [Print] Japan |
PMID | 3468274
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Biological Transport
- Bronchitis
(drug therapy, metabolism)
- Cefotetan
- Cephamycins
(blood, metabolism, therapeutic use)
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Respiratory Tract Infections
(drug therapy, metabolism)
- Sputum
(metabolism)
|