Glioma is the most common primary tumour in the central nervous system in adults, and at present, there is no effective treatment to cure this
malignancy. Long noncoding RNAs (lncRNAs) are closely related to tumour progression and have attracted increasing attention in tumour research. However, the role of
lncRNA FGF14-AS2 in
glioma tumorigenesis has not been determined. In the present study, we found that FGF14-AS2 expression was significantly elevated in
glioma tissues and was associated with poor survival in
glioma patients. Silencing FGF14-AS2 inhibited the proliferation, migration and invasion ability of
glioma cells. In vivo assay showed that silencing FGF14-AS2 led to inhibition of tumour growth. In addition, FGF14-AS2 was observed to promote
glioma progression via the miR-320a/E2F1 axis. Moreover, E2F1 could bind to the promoter region of FGF14-AS2, thereby enhancing FGF14-AS2 expression. In conclusion, FGF14-AS2 could accelerate
tumorigenesis of
glioma by forming a feedback loop with the miR-320a/E2F1 axis which suggested that FGF14-AS2 could serve as a therapeutic target for
glioma.