Prostaglandin (F2 alpha) in missed abortion. Intravenous, extra-amniotic and intramuscular administration--a randomized study.

Abstract

Prostaglandin F2-alpha was administered by the intravenous, extra-amniotic and intramuscular routes in three comparable groups of patients with missed abortion, during a randomized study. Out of 45 patients (15 in each group), nine patients (60%) of the intravenous group aborted within a mean time of 16.2 hours, whereas 14 patients (93.4%) of the extra-amniotic group and 12 patients (80%) of the intramuscular group aborted in averaged times of 8.2 and 10.6 hours, respectively. The percentage of complete abortions was highest in the intravenous group 88.8%, followed by the intramuscular group (50%), and the extra-amniotic group (35.7%). Side effects of nausea, vomiting, diarrhoea and shivering were observed in all groups studied, but were marginally higher in the intravenous group.

• Authors: A S Thavarasah, S A Almohdzar
• Journal: Biological research in pregnancy and perinatology (Biol Res Pregnancy Perinatol) Vol. 7 Issue 3 Pg. 106-10 ( 1986) ISSN: 0724-438X [Print] Germany
• PMID: 3465375 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Prostaglandins F
• Dinoprost

Topics

• Abortion, Missed (therapy)
• Adult
• Amnion (drug effects)
• Dinoprost
• Female
• Humans
• Infusions, Intravenous
• Injections
• Injections, Intramuscular
• Pregnancy
• Prostaglandins F (administration & dosage, adverse effects)
• Uterine Contraction (drug effects)