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4'-Thioadenosine as a novel inhibitor of S-adenosylhomocysteine hydrolase and an inducer for the differentiation of HL-60 human leukemia cells.

AuthorsG A Miura, R K Gordon, J A Montgomery, P K Chiang
JournalAdvances in experimental medicine and biology (Adv Exp Med Biol) Vol. 195 Pt B Pg. 667-72 ( 1986) ISSN: 0065-2598 [Print] United States
PMID3464165 (Publication Type: Journal Article)
Chemical References
  • Purine Nucleotides
  • Thionucleosides
  • Homocysteine
  • 4'-thioadenosine
  • S-Adenosylmethionine
  • S-Adenosylhomocysteine
  • Hydrolases
  • Adenosylhomocysteinase
  • Adenosine
Topics
  • Adenosine (analogs & derivatives, pharmacology)
  • Adenosylhomocysteinase
  • Cell Differentiation (drug effects)
  • Cell Line
  • Chromatography, High Pressure Liquid
  • Homocysteine (analogs & derivatives)
  • Humans
  • Hydrolases (antagonists & inhibitors)
  • Leukemia, Myeloid, Acute (enzymology, pathology)
  • Purine Nucleotides (metabolism)
  • S-Adenosylhomocysteine (metabolism)
  • S-Adenosylmethionine (analogs & derivatives, metabolism)
  • Thionucleosides (pharmacology)

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