[Fundamental and clinical studies on imipenem/cilastatin sodium in the field of obstetrics and gynecology].
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| Abstract |
The following results were obtained during pharmacokinetic, bacteriological and clinical evaluation of the usefulness of the combination (1:1) of imipenem (MK-0787) and cilastatin sodium (MK-0791), an inhibitor of dehydropeptidase-I, in the treatment of patients with obstetric and gynecologic infections. Plasma concentrations of MK-0787 in antecubital vein and uterine artery were 18.2 micrograms/ml and 16.4 micrograms/ml, respectively, and of MK-0791 were 9.5 micrograms/ml and 10.3 micrograms/ml, respectively, at 1.28 hours after the end of a drip infusion of 0.5 g/0.5 g of MK-0787/MK-0791. Plasma concentrations of both MK-0787 and MK-0791 decreased slowly, and concentrations of the former in antecubital vein and uterine artery were 0.7 micrograms/ml and 1.0 micrograms/ml, respectively, and of the latter were 1.5 micrograms/ml and 1.9 micrograms/ml, respectively at 2.83 hours after the end of a drip infusion. Concentrations of the 2 agents in female genital tissues decreased with increasing time in a manner similar to concentrations in the plasma. Clinical responses in 10 patients were excellent in 2 and good in 8, and the efficacy rate was 100 percent. Organisms were isolated from all 10 patients before the treatment, but were eradicated in 9 patients by the treatment. No side effects were observed, but increase of eosinocytes was observed in 1 patient.
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| Authors | S Takamura, T Hata, J Kumagaya, T Yamabe |
| Journal | The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 39 Issue 6 Pg. 1620-5 (Jun 1986) ISSN: 0368-2781 [Print] Japan |
| PMID | 3463803 (Publication Type: English Abstract, Journal Article) |
| Chemical References |
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