Cell membrane skeletal protein 4.1R participates in entry of Zika virus into cells.

Abstract

Zika virus (ZIKV) is a typical mosquito-borne flavivirus known to cause severe fetal microcephaly and adult Guillain-Barré syndrome. Currently, there are no specific drugs or licensed vaccines available for ZIKV infection, and further research is required to identify host cell proteins involved in the virus's life cycle. Viruses are known to use host cell membrane skeletal proteins, such as actin and spectrin, to complete cell entry, transportation, and release. Here, based on immunoprecipitation, the Axl and ZIKV envelope (E) protein were shown to interact with the cell membrane skeleton protein 4.1R. Furthermore, deletion of 4.1R significantly reduced virus titer and viral protein synthesis. Our study showed that 4.1R is an important host cell protein during ZIKV infection and may be involved in the process of viral entry into host cells.

• Authors: Shan Su, Xin Liu, Ren-Rong Tian, Kai-Xuan Qiao, Chang-Bo Zheng, Wen-Cong Gao, Liu-Meng Yang, Qiao-Zhen Kang, Yong-Tang Zheng
• Journal: Virus research (Virus Res) Vol. 306 Pg. 198593 (12 2021) ISSN: 1872-7492 [Electronic] Netherlands
• PMID: 34637814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Cytoskeletal Proteins
• Membrane Proteins

Topics

• Animals
• Cell Membrane (metabolism)
• Cytoskeletal Proteins (metabolism)
• Membrane Proteins (metabolism)
• Virus Internalization
• Virus Replication
• Zika Virus (metabolism)
• Zika Virus Infection