Abstract |
Twenty-seven consecutive patients with previously untreated, or minimally treated benign phase Philadelphia-chromosome-positive, chronic myelogenous leukaemia (CML) were treated with partially purified human leucocyte ( alpha) interferon; 24 of the 27 patients responded to therapy achieving either haematological remission (20 patients) or partial haematological remission (four patients). In the responding patients the peripheral white blood cells declined from a median of 89.6 X 10 X 10(9)/l to 4.5 X 10 X 10(9)/l. The serum lactate dehydrogenase declined from a mean of 8.36 Katal/l (492 mu/ml) to 2.8 Katal/l (165 mu/ml), and the vitamin B12 levels declined from 1492 pg/ml to 838 pg/ml. Fifteen patients had splenomegaly. The spleen size normalized in four and decreased by a median of 30% in 10 additional patients. The bone marrow cellularity fell from a median of 100% to a median of 62%. In seven of the 24 responding patients, followed for greater than or equal to 6 months, the percentage of Ph1-positive cells in the bone marrow declined to a median of 70% (range 5-75%). Alpha interferon was found to be an effective therapeutic agent for controlling the myeloid proliferation in CML, and in partially restoring the nonclonal haematopoietic cells in some of the patients.
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Authors | M Talpaz, K McCredie, H Kantarjian, J Trujillo, M Keating, J Gutterman |
Journal | British journal of haematology
(Br J Haematol)
Vol. 64
Issue 1
Pg. 87-95
(Sep 1986)
ISSN: 0007-1048 [Print] England |
PMID | 3463363
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interferon Type I
- L-Lactate Dehydrogenase
- Vitamin B 12
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Topics |
- Adult
- Aged
- Bone Marrow
(pathology)
- Female
- Humans
- Interferon Type I
(adverse effects, therapeutic use)
- Karyotyping
- L-Lactate Dehydrogenase
(blood)
- Leukemia, Myeloid
(genetics, pathology, therapy)
- Male
- Middle Aged
- Philadelphia Chromosome
- Vitamin B 12
(blood)
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