Anorexia induced in rat by D-glucosamine deoxidized at C-1.

Abstract

The effects of D-glucosamine (2-amino-2-deoxy-D-glucose), an endogenous glucose analogue, and 1-deoxy-D-glucosamine on feeding behavior were clarified. Test solutions (24 mumol) were infused into the third cerebroventricle of the rat. Glucosamine induced a feeding episode within 30 min after infusion and then prolonged the ensuing postprandial intermeal interval for the first 4 h of the dark period, while glucose suppressed feeding by decreasing meal size. Ventricular injection of 1-deoxyglucosamine potently suppressed feeding in a dose-related manner by affecting all meal parameters, and oral administration of 2,400 mumol also induced anorexia. Changes in activity of glucose-sensitive neurons in the lateral hypothalamus and glucoreceptor neurons in the ventromedial hypothalamus after electrophoretic application of glucosamine and 1-deoxyglucosamine were compatible with behavior changes. The results indicate that replacement of a hydroxyl group by an amino group at C-2 of the glucose molecule affects feeding behavior and deoxidation of C-1 potently induces anorexia.

• Authors: K Fujimoto, T Sakata, T Shiraishi, K Kurata, K Terada, H Etou
• Journal: The American journal of physiology (Am J Physiol) Vol. 251 Issue 3 Pt 2 Pg. R481-91 (Sep 1986) ISSN: 0002-9513 [Print] United States
• PMID: 3463216 (Publication Type: Journal Article)

Chemical References

• 1-deoxyglucosamine
• Glucosamine

Topics

• Administration, Oral
• Animals
• Anorexia (chemically induced)
• Cerebral Ventricles (physiology)
• Chemical Phenomena
• Chemistry
• Darkness
• Drinking (drug effects)
• Eating (drug effects)
• Feeding and Eating Disorders (chemically induced)
• Glucosamine (analogs & derivatives, metabolism, pharmacology)
• Hypothalamus (cytology, drug effects, physiology)
• Injections, Intraventricular
• Light
• Locomotion (drug effects)
• Male
• Oxidation-Reduction
• Rats
• Rats, Inbred Strains
• Time Factors