Indirect comparison of the diagnostic performance of 18F-FDG PET/CT and MRI in differentiating benign and malignant ovarian or adnexal tumors: a systematic review and meta-analysis.

Abstract

OBJECTIVE:

To compare the value of fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging (MRI) in differentiating benign and malignant ovarian or adnexal tumors.

MATERIALS AND METHODS:

English articles reporting on the diagnostic performance of MRI or 18F-FDG PET/CT in identifying benign and malignant ovarian or adnexal tumors published in PubMed and Embase between January 2000 and January 2021 were included in the meta-analysis. Two authors independently extracted the data. If the data presented in the study report could be used to construct a 2 × 2 contingency table comparing 18F-FDG PET/CT and MRI, the studies were selected for the analysis. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to evaluate the quality of the included studies. Forest plots were generated according to the sensitivity and specificity of 18F-FDG PET/CT and MRI.

RESULTS:

A total of 27 articles, including 1118F-FDG PET/CT studies and 17 MRI studies on the differentiation of benign and malignant ovarian or adnexal tumors, were included in this meta-analysis. The pooled sensitivity and specificity for 18F-FDG PET/CT in differentiating benign and malignant ovarian or adnexal tumors were 0.94 (95% CI, 0.87-0.97) and 0.86 (95% CI, 0.79-0.91), respectively, and the pooled sensitivity and specificity for MRI were 0.92 (95% CI: 0.89-0.95) and 0.85 (95% CI: 0.79-0.89), respectively.

CONCLUSION:

While MRI and 18F-FDG PET/CT both showed to have high and similar diagnostic performance in the differential diagnosis of benign and malignant ovarian or adnexal tumors, MRI, a promising non-radiation imaging technology, may be a more suitable choice for patients with ovarian or accessory tumors. Nonetheless, prospective studies directly comparing MRI and 18F-FDG PET/CT diagnostic performance in the differentiation of benign and malignant ovarian or adnexal tumors are needed.

• Authors: Xianwen Hu, Dandan Li, Zhigang Liang, Yan Liao, Ling Yang, Rui Wang, Pan Wang, Jiong Cai
• Journal: BMC cancer (BMC Cancer) Vol. 21 Issue 1 Pg. 1080 (Oct 06 2021) ISSN: 1471-2407 [Electronic] England
• PMID: 34615498 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)
• Copyright: © 2021. The Author(s).

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Adnexal Diseases (diagnostic imaging)
• Adult
• Diagnosis, Differential
• Female
• Fluorodeoxyglucose F18
• Humans
• Magnetic Resonance Imaging
• Middle Aged
• Ovarian Neoplasms (diagnostic imaging)
• Positron Emission Tomography Computed Tomography
• Publication Bias
• Radiopharmaceuticals
• Sensitivity and Specificity