Abstract | BACKGROUND AND AIMS: METHODS: A randomised double-blind study was conducted on 200 American Society of Anesthesiologists (ASA) II-III parturients undergoing caesarean section under subarachnoid block (SAB) who were randomised to two groups A and B to receive variable rate, manually controlled infusions of phenylephrine and norepinephrine targeting maintenance of SBP to 100% of the baseline value. Maternal haemodynamics especially episodes of hypotension, IONV and vasopressor consumption were observed and recorded. RESULTS: A statistically significant trend of lower SBP was observed during the first 6 min following intrathecal injection in group A (P value - 0.000). Though a greater number of parturients experienced ≥1 episode of hypotension in Group A vs Group B (13% vs 9%), the difference was, however, statistically insignificant. The incidence of bradycardia was higher in group A than in group B (16% vs 1%) and was found to be statistically significant (P < 0.05). The episodes of hypertension, IONV, maternal vasopressor consumption and neonatal Apgar score were comparable among both the groups. CONCLUSION: A dilute solution of norepinephrine infusion is comparably efficacious to the current gold standard vasopressor phenylephrine in maintaining blood pressure following spinal anaesthesia for caesarean delivery, with a significantly lower incidence of bradycardia.
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Authors | Kanika Goel, Neeru Luthra, Namrata Goyal, Anju Grewal, Ashima Taneja |
Journal | Indian journal of anaesthesia
(Indian J Anaesth)
Vol. 65
Issue 8
Pg. 600-605
(Aug 2021)
ISSN: 0019-5049 [Print] India |
PMID | 34584283
(Publication Type: Journal Article)
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Copyright | Copyright: © 2021 Indian Journal of Anaesthesia. |