Randomized Phase II Study of PARP Inhibitor ABT-888 (Veliparib) with Modified FOLFIRI versus FOLFIRI as Second-line Treatment of Metastatic Pancreatic Cancer: SWOG S1513.

Abstract

PURPOSE:

PARP inhibitors synergize with topoisomerase inhibitors, and veliparib plus modified (m) FOLFIRI (no 5-FU bolus) had preliminary activity in metastatic pancreatic cancers. This study evaluated the safety and efficacy of second-line treatment with veliparib and mFOLFIRI versus FOLFIRI (control) for metastatic pancreatic cancer.

PATIENTS AND METHODS:

This randomized phase II clinical trial led by the SWOG Cancer Research Network enrolled patients between September 1, 2016 and December 13, 2017. The median follow-up was 9 months (IQR 1-27). BRCA1/2 and homologous recombination DNA damage repair (HR-DDR) genetic defects were tested in blood and tumor biopsies. Patients received veliparib 200 mg twice daily, days 1-7 with mFOLFIRI days 3-5, or FOLFIRI in 14-day cycles.

RESULTS:

After 123 of planned 143 patients were accrued, an interim futility analysis indicated that the veliparib arm was unlikely to be superior to control, and the study was halted. Median overall survival (OS) was 5.4 versus 6.5 months (HR, 1.23; P = 0.28), and median progression-free survival (PFS) was 2.1 versus 2.9 months (HR, 1.39; P = 0.09) with veliparib versus control. Grade 3/4 toxicities were more common with veliparib (69% vs. 58%, P = 0.23). For cancers with HR-DDR defects versus wild-type, median PFS and OS were 7.3 versus 2.5 months (P = 0.05) and 10.1 versus 5.9 months (P = 0.17), respectively, with FOLFIRI, and 2.0 versus 2.1 months (P = 0.62) and 7.4 versus 5.1 months (P = 0.10), respectively, with veliparib plus mFOLFIRI.

CONCLUSIONS:

Veliparib plus mFOLFIRI did not improve survival for metastatic pancreatic cancer. FOLFIRI should be further studied in pancreatic cancers with HR-DDR defects.

• Authors: E Gabriela Chiorean, Katherine A Guthrie, Philip A Philip, Elizabeth M Swisher, Florencia Jalikis, Michael J Pishvaian, Jordan Berlin, Marcus S Noel, Jennifer M Suga, Ignacio Garrido-Laguna, Dana Backlund Cardin, Marc R Radke, Mai Duong, Shay Bellasea, Andrew M Lowy, Howard S Hochster
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 27 Issue 23 Pg. 6314-6322 (12 01 2021) ISSN: 1557-3265 [Electronic] United States
• PMID: 34580114 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Comment)
• Copyright: ©2021 American Association for Cancer Research.

Chemical References

• Benzimidazoles
• Poly(ADP-ribose) Polymerase Inhibitors
• veliparib

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Benzimidazoles (adverse effects)
• Humans
• Pancreatic Neoplasms (drug therapy, genetics)
• Poly(ADP-ribose) Polymerase Inhibitors (adverse effects)