[Experimental evaluation of the role of blood flow inhibition in hyperglycemia-enhanced radiation damage to tumors].

Abstract

The authors provided experimental assessment of the role of the blood flow inhibition in enhancement of radiation injury to tumors using short-term hyperglycemia. Experiments on mice with Ehrlich solid carcinoma showed the dependence of a rise of the antitumor effect of preceding radiation induced by glucose and glucose combined with mexamine on a degree of the blood flow inhibition under the influence of these modifying agents. It was established that a considerable enhancement of radiation injury occurred but in such tumors where short-term hyperglycemia and mexamine decreased the blood flow level not less than 5-10 fold as estimated by 133Xe clearance. The results of the above experiments showed that noticeable inhibition of the blood flow in tumors was a necessary though, probably, not the only condition for a high efficacy of short-term hyperglycemia used as an adjuvant to radiotherapy.

• Authors: S V Kozin, A I Sevast'ianov, S P Iarmonenko
• Journal: Meditsinskaia radiologiia (Med Radiol (Mosk)) Vol. 31 Issue 4 Pg. 55-8 (Apr 1986) ISSN: 0025-8334 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'naia otsenka roli ingibirovaniia krovotoka v usilenii giperglikemieĭ luchevogo porazheniia opukholeĭ.
• PMID: 3457233 (Publication Type: English Abstract, Journal Article)

Chemical References

• Blood Glucose
• 5-Methoxytryptamine

Topics

• 5-Methoxytryptamine (therapeutic use)
• Animals
• Blood Glucose (physiology)
• Carcinoma, Ehrlich Tumor (blood supply, drug therapy, radiotherapy)
• Combined Modality Therapy
• Male
• Mice