Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene.

Abstract

The carcinogenicity of 1-nitropyrene [(1-NP) CAS: 5522-43-0] and 1,6-dinitropyrene [(1,6-DNP) CAS: 42397-64-8] was examined by their direct injection in a beeswax-tricaprylin vehicle into the lung of male F344/DuCrj rats. Of 28 rats given 0.15 mg of 1,6-DNP, 21 (75%) developed squamous cell carcinomas, 2 (7%) developed undifferentiated carcinomas, and 2 (7%) had squamous metaplasias in the lung by 72 weeks. In 32 rats that received 1.5 mg of 1-NP, neither carcinoma nor squamous metaplasia was induced. In all 19 rats (100%) given 0.5 mg of 3-methylcholanthrene [(MCA) CAS: 56-49-5], squamous cell carcinomas were induced earlier than in rats treated with 1,6-DNP. In 1 of 31 rats (3%) given the beeswax-tricaprylin vehicle only, squamous metaplasia was induced. Distant metastases of induced tumors were observed in 4 rats treated with 1,6-DNP and in 1 rat receiving MCA. Two lung tumors induced by 1,6-DNP were successively transplanted into the same strain of rats for 3 generations.

• Authors: T Maeda, K Izumi, H Otsuka, Y Manabe, T Kinouchi, Y Ohnishi
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 76 Issue 4 Pg. 693-701 (Apr 1986) ISSN: 0027-8874 [Print] United States
• PMID: 3457204 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Pyrenes
• Methylcholanthrene
• 1,6-dinitropyrene
• 1-nitropyrene

Topics

• Animals
• Carcinogens
• Carcinoma, Squamous Cell (chemically induced, pathology)
• Kidney Neoplasms (secondary)
• Lung Neoplasms (chemically induced, pathology)
• Male
• Methylcholanthrene
• Pyrenes (toxicity)
• Rats
• Rats, Inbred F344