HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

High dose Ara-C related leukoencephalopathy.

Abstract
Two patients with acute myelomonocytic leukemia in central nervous system relapse developed clinical signs and computerized tomographic evidence of leukoencephalopathy five to seven days after intravenous high dose Ara-C therapy. The first patient had received 30 gm of intravenous Ara-C with cranial irradiation (1680 rad in 2 fractions) and intrathecal Ara-C (100 mg X twice) for an intracerebral chloroma and leptomeningeal leukemia. In this patient the leukoencephatlopathy was probably a result of a synergistic effect of the concomitant triple therapy. The second patient had received intrathecal administration of Ara-C and methotrexate for five and one-half months prior to intravenous Ara-C therapy. He developed altered mental status after 24 gm of intravenous Ara-C infusion. CT scan showed changes in the white matter compatible with leukoencephalopathy. In this patient the intravenous Ara-C probably was the precipitating factor of the development of leukoencephalopathy. The possible mechanism of the Ara-C induced leukoencephalopathy is discussed.
AuthorsT L Hwang, W K Yung, Y Y Lee, A Borit, W S Fields
JournalJournal of neuro-oncology (J Neurooncol) Vol. 3 Issue 4 Pg. 335-9 ( 1986) ISSN: 0167-594X [Print] United States
PMID3457103 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cytarabine
Topics
  • Adult
  • Brain (drug effects, pathology)
  • Cytarabine (administration & dosage, adverse effects)
  • Female
  • Humans
  • Leukemia, Myeloid, Acute (drug therapy)
  • Leukoencephalopathy, Progressive Multifocal (chemically induced)
  • Male
  • Middle Aged
  • Time Factors
  • Tomography, X-Ray Computed

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: